Noncommunicable diseases, especially those heart disease and cancersare the main cause of death and diseases in Spain. This marks the incessant roadmap of science and research to find a cure or treatment that can combat them in the most effective way possible. But would a world be possible without them? Will this century see how they are eradicated? According to the CEO of the pharmaceutical company Moderna, Dr. Paul Burton, that reality may be at hand. Burton himself predicted that the cancer and heart disease vaccines could be available by the end of the current decade, more specifically 2030. But there is more, according to Burton, Moderna will be able to offer vaccines for “all types of disease” in just five years. The technology of messenger mRNA (mRNA), which was used in Moderna’s vaccine against COVID-19, can also be applied to other autoimmune and rare diseases. As? mRNA set the tone for a new era in this field.
Messenger RNA (mRNA) technology, which was used in the modern vaccine against COVID-19, showed how mRNA could be used to fight these diseases with promising results. Burton said that within 10 years, mRNA technology will be used to identify the genetic cause of a disease and repair it.
How it works against cancer
OmRNA vaccines work by instructing cells to make a protein that triggers a immune response against a specific pathogen such as Covid. Scientists say these instructions can also be modified to get cells to do what they want. cancer cell surface antigens alerting the immune system to the cancer cells and triggering an attack. Doctors say mRNA vaccines can be modified for each patient to explain the different types of cancer and the differences between patients.
To administer the mRNA cancer vaccine, doctors took a biopsy of the patient’s tumor and would encode the vaccine to produce the same antigen. The vaccine would then be administered, activating the cells to produce the antigen and trigger an immune response against it. Immune cells would be trained to kill any cancer cells and detect cells that come back in the future.
Dr. Burton said it is possible to offer personalized cancer vaccines to treat various types of tumors all around the world. However, although Dr. Burton is confident that personalized cancer vaccines will be able to treat different types of tumors and will be accessible to people around the world, in the early stages they would be highly personalized and expensive.
What stage are they currently in?
are being carried out vaccine tests of mRNA against cancer in UK and US, including Moderna’s cancer vaccine, which received “breakthrough therapy” status from the FDA in February. Results are expected in the coming months, and the vaccine could be used in conjunction with immunotherapy to treat patients with advanced melanoma who are at increased risk of tumor recurrence.
In a phase two study, it was shown that the combination of a Immunotherapy and a vaccine reduced the risk of relapse or death after surgery by 44% compared to the immunotherapy drug alone.